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1

Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24

Toshiyuki Sakaki, Natsumi Sawada, Koichiro Komai, Shunichi Shiozawa, Sachiko Yamada, Keiko Yamamoto, Yoshihiko Ohyama, Kuniyo Inouye

Journal:

Year:

2000

Language:

english

File:

PDF, 891 KB

english, 2000

2

Potent Antiproliferative Effects of 25-Hydroxy-16-ene-23-yne-vitamin D 3 That Resists the Catalytic Activity of Both CYP27B1 and CYP24A1

Rhieu, Steve Y., Annalora, Andrew J., LaPorta, Erika, Welsh, JoEllen, Itoh, Toshimasa, Yamamoto, Keiko, Sakaki, Toshiyuki, Chen, Tai C., Uskokovic, Milan R., Reddy, G. Satyanarayana

Journal:

Journal of Cellular Biochemistry

Year:

2014

Language:

english

File:

PDF, 3.52 MB

english, 2014

3

CYP24A1 as a Potential Target for Cancer Therapy

Sakaki, Toshiyuki, Yasuda, Kaori, Kittaka, Atsushi, Yamamoto, Keiko, Chen, Tai

Journal:

Anti-Cancer Agents in Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 684 KB

english, 2014

4

Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P450

Toshiyuki Sakaki, Hiroshi Sugimoto, Keiko Hayashi, Kaori Yasuda, Eiji Munetsuna, Masaki Kamakura, Shinichi Ikushiro, Yoshitsugu Shiro

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2011

Language:

english

File:

PDF, 1.01 MB

english, 2011

5

Relation between myocardial response to dobutamine stress and sympathetic nerve activation in patients with idiopathic dilated cardiomyopathy: A comparison of123I-MIBG scintigraphic and echocardiographic data

Hitoshi Naruse, Tohru Arii, Tomohiro Kondo, Makoto Ohnishi, Takatoshi Sakaki, Keiko Takahashi, Miho Masai, Mitsumasa Ohyanagi, Tadaaki Iwasaki, Minoru Fukuchi

Journal:

Annals of Nuclear Medicine

Year:

2000

Language:

english

File:

PDF, 672 KB

english, 2000

6

Cilnidipine as an agent to lower blood pressure without sympathetic nervous activation as demonstrated by iodine-123 metaiodobenzylguanidine imaging in rat hearts

Takatoshi Sakaki, Hitoshi Naruse, Miho Masai, Keiko Takahashi, Mitsumasa Ohyanagi, Tadaaki Iwasaki, Minoru Fukuchi

Journal:

Annals of Nuclear Medicine

Year:

2003

Language:

english

File:

PDF, 863 KB

english, 2003

7

Early lineage switch in an infant acute lymphoblastic leukemia

Hisano Sakaki, Hirokazu Kanegane, Keiko Nomura, Kumiko Goi, Kanji Sugita, Masayoshi Miura, Eiichi Ishii, Toshio Miyawaki

Journal:

International Journal of Hematology

Year:

2009

Language:

english

File:

PDF, 198 KB

english, 2009

8

Micellization of an asymmetric block copolymer in mixed selective solvents

Chikako Honda, Keiko Sakaki, Takuhei Nose

Journal:

Year:

1994

Language:

english

File:

PDF, 987 KB

english, 1994

9

Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1 : Enzymes and catalysis

Keiko Hayashi, Kaori Yasuda, Hiroshi Sugimoto, Shinichi Ikushiro, Masaki Kamakura, Atsushi Kittaka, Ronald L. Horst, Tai C. Chen, Miho Ohta, Yoshitsugu Shiro, Toshiyuki Sakaki

Journal:

Year:

2010

Language:

english

File:

PDF, 841 KB

english, 2010

10

Transformation of Ba/F3 cells and Rat-1 cells by ETV6/ARG

Tokunaga, Katsushi, Kruh, Gary D, Sato, Yuko, Iijima, Yoshimi, Okuda, Keiko, Tojo, Arinobu, Tri, Nguyen Khanh, Setoyama, Misao, Sakaki, Yoshiyuki, Asano, Shigetaka

Journal:

Year:

2002

Language:

english

File:

PDF, 316 KB

english, 2002

11

Role of Gln 85 of human CYP27A1 in 25-hydroxyvitamin D3-binding and protein folding

Natsumi Sawada, Keiko Yamamoto, Sachiko Yamada, Shinichi Ikushiro, Masaki Kamakura, Miho Ohta, Kuniyo Inouye, Toshiyuki Sakaki

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 694 KB

english, 2007

12

Homology modeling of human 25-hydroxyvitamin D3 1α-hydroxylase (CYP27B1) based on the crystal structure of rabbit CYP2C5

Keiko Yamamoto, Hiroyuki Masuno, Natsumi Sawada, Toshiyuki Sakaki, Kuniyo Inouye, Masaji Ishiguro, Sachiko Yamada

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2004

Language:

english

File:

PDF, 370 KB

english, 2004

13

Substitution at carbon 2 of 19-nor-1α,25-dihydroxyvitamin D3 with 3-hydroxypropyl group generates an analogue with enhanced chemotherapeutic potency in PC-3 prostate cancer cells

Diego Iglesias-Gato, Shasha Zheng, John N. Flanagan, Lan Jiang, Atsushi Kittaka, Toshiyuki Sakaki, Keiko Yamamoto, Toshimasa Itoh, Nathan K. LeBrasseur, Gunnar Norstedt, Tai C. Chen

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 707 KB

english, 2011

14

Altered actin binding with myosin mutation in hypertrophic cardiomyopathy and sudden death

Masayoshi Kato, Kenji Takazawa, Akinori Kimura, JohannC. Rüegg, Keiko Amano, Yuepang Wang, Yoshiyuki Sakaki, Teruhiko Toyo-oka

Journal:

Year:

1995

Language:

english

File:

PDF, 134 KB

english, 1995

15

Possibility of application of cytochrome P450 to bioremediation of dioxins

Sakaki, Toshiyuki, Yamamoto, Keiko, Ikushiro, Shinichi

Journal:

Biotechnology and Applied Biochemistry

Year:

2013

Language:

english

File:

PDF, 339 KB

english, 2013

16

Allogeneic Bone Marrow Transplantation Appears to Ameliorate IgA Nephropathy in a Patient with X-linked Thrombocytopenia

Hoshino, Akihiro, Shimizu, Masaki, Matsukura, Hiroyoshi, Sakaki-Nakatsubo, Hisano, Nomura, Keiko, Miyawaki, Toshio, Kanegane, Hirokazu

Journal:

Journal of Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 302 KB

english, 2014

17

Crystal Structure of CYP105A1 (P450SU-1) in Complex with 1α,25-Dihydroxyvitamin D 3†,‡

Sugimoto, Hiroshi, Shinkyo, Raku, Hayashi, Keiko, Yoneda, Sachiyo, Yamada, Masato, Kamakura, Masaki, Ikushiro, Shin-ichi, Shiro, Yoshitsugu, Sakaki, Toshiyuki

Journal:

Year:

2008

Language:

english

File:

PDF, 3.68 MB

english, 2008

18

Structure-Based Design of a Highly Active Vitamin D Hydroxylase from Streptomyces griseolus CYP105A1 †‡

Hayashi, Keiko, Sugimoto, Hiroshi, Shinkyo, Raku, Yamada, Masato, Ikeda, Shinnosuke, Ikushiro, Shinichi, Kamakura, Masaki, Shiro, Yoshitsugu, Sakaki, Toshiyuki

Journal:

Year:

2008

Language:

english

File:

PDF, 3.99 MB

english, 2008

19

Interaction between Mitochondrial CYP27B1 and Adrenodoxin: Role of Arginine 458 of Mouse CYP27B1 †

Urushino, Naoko, Yamamoto, Keiko, Kagawa, Norio, Ikushiro, Shinichi, Kamakura, Masaki, Yamada, Sachiko, Kato, Shigeaki, Inouye, Kuniyo, Sakaki, Toshiyuki

Journal:

Year:

2006

Language:

english

File:

PDF, 278 KB

english, 2006

20

Giardiasis in a patient undergoing chemotherapy for retinoblastoma and acute myelogenous leukemia

Otsubo, Keisuke, Sakaki-Nakatsubo, Hisano, Taneichi, Hiromichi, Nomura, Keiko, Miyawaki, Toshio, Tokoro, Masaharu, Kanegane, Hirokazu

Journal:

Pediatrics International

Year:

2013

Language:

english

File:

PDF, 411 KB

english, 2013

21

A Case of Pulmonary Sarcoma with Significant Extension into the Right Lung

Inoue, Yoshiaki, Izumi, Yotaro, Sakaki, Kenjiro, Abe, Keiko, Oka, Teruaki, Tamaru, Jun-Ichi, Sugiyama, Ato, Aoki, Kohei, Fukuda, Hiroki, Gika, Masatoshi, Imanaka, Kazuhito, Nakayama, Mitsuo

Journal:

Case Reports in Medicine

Year:

2014

Language:

english

File:

PDF, 1.78 MB

english, 2014

22

Mammalian Cytochrome P450-Dependent Metabolism of Polychlorinated Dibenzo-p-dioxins and Coplanar Polychlorinated Biphenyls

Inui, Hideyuki, Itoh, Toshimasa, Yamamoto, Keiko, Ikushiro, Shin-Ichi, Sakaki, Toshiyuki

Journal:

International Journal of Molecular Sciences

Year:

2014

Language:

english

File:

PDF, 976 KB

english, 2014

23

Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1

Hayashi, Keiko, Yasuda, Kaori, Yogo, Yuya, Takita, Teisuke, Yasukawa, Kiyoshi, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki

Journal:

Biochemical and Biophysical Research Communications

Year:

2016

Language:

english

File:

PDF, 909 KB

english, 2016

24

Structural determinants of the position of 2,3′,4,4′,5-pentachlorobiphenyl (CB118) hydroxylation by mammalian cytochrome P450 monooxygenases

Mise, Shintaro, Haga, Yuki, Itoh, Toshimasa, Kato, Akira, Fukuda, Itsuko, Goto, Erika, Yamamoto, Keiko, Yabu, Miku, Matsumura, Chisato, Nakano, Takeshi, Sakaki, Toshiyuki, Inui, Hideyuki

Journal:

Toxicological Sciences

Year:

2016

Language:

english

File:

PDF, 792 KB

english, 2016

25

Exploitation of Na + -Selective Electrodes for Protein Solutions from Crown-Bridged Calix[4]quinones

Yamamoto, Hiromasa, Ueda, Keiko, Suenaga, Hikaru, Sakaki, Toru, Shinkai, Seiji

Journal:

Chemistry Letters

Year:

1996

File:

PDF, 349 KB

1996

26

Polycyclic N-hetero compounds. XXIII Synthesis and antidepressive activity of 4-substituted 5,6-dihydrobenzo(h)quinazolines.

HIROTA, TAKASHI, KAWANISHI, KEIKO, SAKAKI, KENJI, NAMBA, TETSUTO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1986

File:

PDF, 384 KB

1986

27

The roles of cytochrome P450 enzymes in prostate cancer development and treatment

Chen, Tai C., Sakaki, Toshiyuki, Yamamoto, Keiko, Kittaka, Atsushi

Journal:

Anticancer research

Year:

2012

Language:

english

File:

PDF, 237 KB

english, 2012

28

Protein engineering of CYP105s for their industrial uses

Yasuda, Kaori, Sugimoto, Hiroshi, Hayashi, Keiko, Takita, Teisuke, Yasukawa, Kiyoshi, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Shiro, Yoshitsugu, Sakaki, Toshiyuki

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2017

Language:

english

File:

PDF, 813 KB

english, 2017

29

3P099 Crystal structure of cytochrome P450SU-1 (CYP105A1) reveals the mechanism of two-step activation of vitamin D_3(Hemeproteins,Poster Presentations)

Sugimoto, Hiroshi, Shinkyo, Raku, Hayashi, Keiko, Yamada, Masato, Nakabayashi, Sachie, Ikeda, Shinnosuke, Kamakura, Masaki, Ikushiro, Shin-ichi, Shiro, Yoshitsugu, Sakaki, Toshiyuki

Journal:

Seibutsu Butsuri

Year:

2007

File:

PDF, 250 KB

2007

30

Structural Variation of Self-Organized Mg Hydride Nanoclusters in Immiscible Ti Matrix by Hydrogenation

Asano, Kohta, Kim, Hyunjeong, Sakaki, Kouji, Jimura, Keiko, Hayashi, Shigenobu, Nakamura, Yumiko, Ikeda, Kazutaka, Otomo, Toshiya, Machida, Akihiko, Watanuki, Tetsu

Journal:

Inorganic Chemistry

Year:

2018

Language:

english

File:

PDF, 2.71 MB

english, 2018

31

Two Kindreds with Familial Alzheimer's Disease. Analysis of the APP717 Mutation and the Mutated Genes for the Prion Protein.

Nagano, Keiko, Miki, Tetsuro, Yoshioka, Katsuyoshi, Katsumi, Dohura, Katsuya, Tomohiro, Takeda, Masatoshi, Ikeda, Manabu, Tanabe, Hirotaka, Nishimura, Tsuyoshi, Sakaki, Yoshitaka, Ogihara, Toshio

Journal:

Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics

Year:

1992

File:

PDF, 1.61 MB

1992

32

Two Kindreds with Familial Alzheimer's Disease. Analysis of the APP717 Mutation and the Mutated Genes for the Prion Protein.

Nagano, Keiko, Miki, Tetsuro, Yoshioka, Katsuyoshi, Katsumi, Dohura, Katsuya, Tomohiro, Takeda, Masatoshi, Ikeda, Manabu, Tanabe, Hirotaka, Nishimura, Tsuyoshi, Sakaki, Yoshitaka, Ogihara, Toshio

Journal:

Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics

Year:

1992

File:

PDF, 1.61 MB

1992